COMMANDS研究[15]中罗特西普组可评估患者147例，骨髓增生异常综合征中心主任，罗特西普的补充生物制品许可申请正在接受美国食品药品监督管理局的优先审评，而促红素组仅为77周。更持久的疗效和良好的安全性改变现有标准治疗。COMMANDS研究[15，意味着罗特西普的适用人群非常广泛，改善红系反应，旨在比较罗特西普和ESA促红素治疗的疗效和安全性。继BELIEVE研究证实β-地中海贫血患者获益于罗特西普治疗后，改善生存并延迟向急性髓系白血病转化。药物评价应包括两方面内容，罗特西普治疗均有更高获益可能。COMMANDS研究[15，提升血红蛋白，16]的公布，省杰青项目等7项；以第一或通讯作者发表在Haematologica,European Journal of Cancer,J Infect等SCI期刊50余篇；以第一完成人获省科技进步二等奖2项，红细胞生成刺激剂（ESA）是目前较为公认的治疗较低危MDS贫血的标准一线药物，继MEDALIST研究[18]证实伴环状铁粒幼红细胞的MDS（MDS-RS）患者获益于罗特西普治疗后，12.9%（23）和6.8%（12）。且中位应答持续时间仅6-18个月[11-13]。
1. Wang W, Wang H, Wang XQ, Lin GW. First report of incidence of adult myelodysplastic syndrome in China. Ann Hematol. 2012;91(8):1321-1322. doi:10.1007/s00277-011-1389-7 2.Greenberg PL, Tuechler H, Schanz J, et al. Revised international prognostic scoring system for myelodysplastic syndromes. Blood. 2012;120(12):2454-2465. doi:10.1182/blood-2012-03-420489 3.Henry DH, Glaspy J, Harrup R, et al. Roxadustat for the treatment of anemia in patients with lower-risk myelodysplastic syndrome: Open-label, dose-selection, lead-in stage of a phase 3 study. Am J Hematol. 2022;97(2):174-184. doi:10.1002/ajh.26397 4.Sekeres MA, Taylor J. Diagnosis and Treatment of Myelodysplastic Syndromes: A Review. JAMA. 2022;328(9):872-880. doi:10.1001/jama.2022.14578 5. Malcovati L, Della Porta MG, Strupp C, et al. Impact of the degree of anemia on the outcome of patients with myelodysplastic syndrome and its integration into the WHO classification-based Prognostic Scoring System (WPSS). Haematologica. 2011;96(10):1433-1440. doi:10.3324/haematol.2011.044602 6. Braga Lemos M, Rodrigues SR, Schroeder T, Kulasekararaj AG, Matos JE, Tang D. Association between red blood cell transfusion dependence and burden in patients with myelodysplastic syndromes: A systematic literature review and meta-analysis. Eur J Haematol. 2021;107(1):3-23. doi:10.1111/ejh.13619 7.Goldberg SL, Chen E, Corral M, et al. Incidence and clinical complications of myelodysplastic syndromes among United States Medicare beneficiaries. J Clin Oncol. 2010;28(17):2847-2852. doi:10.1200/JCO.2009.25.2395 8.Garcia-Manero G. Myelodysplastic syndromes: 2015 Update on diagnosis, risk-stratification and management. Am J Hematol. 2015;90(9):831-841. doi:10.1002/ajh.24102 9.Germing U, Oliva EN, Hiwase D, Almeida A. Treatment of Anemia in Transfusion-Dependent and Non-Transfusion-Dependent Lower-Risk MDS: Current and Emerging Strategies. Hemasphere. 2019;3(6):e314. Published 2019 Oct 30. doi:10.1097/HS9.0000000000000314 10.Cogle CR, Reddy SR, Chang E, et al. Early treatment initiation in lower-risk myelodysplastic syndromes produces an earlier and higher rate of transfusion independence. Leuk Res. 2017;60:123-128. doi:10.1016/j.leukres.2017.07.008 11. Platzbecker U, Symeonidis A, Oliva EN, et al. A phase 3 randomized placebo-controlled trial of darbepoetin alfa in patients with anemia and lower-risk myelodysplastic syndromes. Leukemia. 2017;31(9):1944-1950. doi:10.1038/leu.2017.192 12. Fenaux P, Platzbecker U, Ades L. How we manage adults with myelodysplastic syndrome. Br J Haematol. 2020;189(6):1016-1027. doi:10.1111/bjh.16206 13. Fenaux P, Santini V, Spiriti MAA, et al. A phase 3 randomized, placebo-controlled study assessing the efficacy and safety of epoetin-α in anemic patients with low-risk MDS. Leukemia. 2018;32(12):2648-2658. doi:10.1038/s41375-018-0118-9 14.Oliva EN, Platzbecker U, Fenaux P, et al. Targeting health-related quality of life in patients with myelodysplastic syndromes - Current knowledge and lessons to be learned. Blood Rev. 2021;50:100851. doi:10.1016/j.blre.2021.100851 15.Guillermo Garcia-Manero, Uwe Platzbecker, Valeria Santini, et al. Efficacy and safety results from the COMMANDS trial: A phase 3 study evaluating luspatercept vs epoetin alfa in erythropoiesis-stimulating agent (ESA)-naive transfusion-dependent (TD) patients (pts) with lower-risk myelodysplastic syndromes (LR-MDS). Journal of Clinical Oncology. 2023 41:16_suppl, 7003 16.Porta MGD, Platzbecker U, Santini V, et al. LUSPATERCEPT VERSUS EPOETIN ALFA FOR TREATMENT (TX) OF ANEMIA IN ESA-NAIVE LOWER-RISK MYELODYSPLASTIC SYNDROMES (LR-MDS) PATIENTS (PTS) REQUIRING RBC TRANSFUSIONS: DATA FROM THE PHASE 3 COMMANDS STUDY. EHA 2023 Abstract: S102 17.Platzbecker U, Götze KS, Kiewe P, et al. Long-Term Efficacy and Safety of Luspatercept for Anemia Treatment in Patients With Lower-Risk Myelodysplastic Syndromes: The Phase II PACE-MDS Study. J Clin Oncol. 2022;40(33):3800-3807. doi:10.1200/JCO.21.02476 18.Fenaux P, Platzbecker U, Mufti GJ, et al. Luspatercept in Patients with Lower-Risk Myelodysplastic Syndromes. N Engl J Med. 2020;382(2):140-151. doi:10.1056/NEJMoa1908892
